Broad Spectrum Antiviral Immunomodulator

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bioRxiv: Prophylactic intranasal administration of a TLR2 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Pamela C. Proud, Daphne Tsitoura, Robert J. Watson, Brendon Y Chua, Marilyn J. Aram, Kevin R. Bewley, Breeze E. Cavell, Rebecca Cobb, Stuart Dowall, Susan A. Fotheringham, Catherine M. K. Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A. Ryan, Gillian S. Slack, Stephen Thomas, Nadina I. Wand, Paul Yeates, Christophe Demaison, David C. Jackson, Nathan W. Bartlett, Francesca Mercuri, Miles W. Carroll doi: https://doi.org/10.1101/2020.09.25.309914 This article is a preprint and has not been certified by peer review [what does this mean?].

Abstract:

Respiratory viruses such as coronaviruses represent major ongoing global threats, causing epidemics and pandemics with huge economic burden. Rapid spread of virus through populations poses an enormous challenge for outbreak control. Like all respiratory viruses, the most recent novel human coronavirus SARS-CoV-2, initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptomatic, yet highly infectious and readily transmit virus. A therapy that restricts initial replication in the URT has the potential to prevent progression of severe lower respiratory tract disease as well as limiting person-to-person transmission.

We show that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 ferret infection model effectively reduces levels of viral RNA in the nose and throat. The results of our study support clinical development of a therapy based on prophylactic TLR2/6 innate immune activation in the URT to reduce SARS-CoV-2 transmission and provide protection against COVID-19.

Read full research paper at: bioRxv

Read more about product implication from biotechnology company at: Ena Respiratory

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In 1995 At Maui High Performance Computing Center The Maui Scientific Analysis & Visualization of the Environment Program was first incubated. I was the principal investigator of this independant research project which was a joint development between MHPCC, Silicon Graphics Computers (SGI) & NKO.ORG. Using SGI Cosmo Worlds software, we pioneered the development of Internet based 3D virtual reality GIS based interactive worlds. In 1996 with a network of seven high performance SGI workstations we pioneered development of live streaming MPEG-1, MPEG-2, MPEG-4, Real Video and QuickTime Streaming Server utilizing Kassenna MediaBase software. In Maui 2002 we pioneered and tested the first wireless live streaming video using laptop computers and Maui Sky Fiber's portable 3G wireless device. In Maui we pioneered live streaming video using usb modems from AT&T , Verizon as well as live streaming from iPhone 3 over 3G wireless networks. Today The Maui S.A.V.E. Program has diversified into storm tracking including visualization and analysis of large, memory-intensive gridded data sets such as the National Hurricane Center's wind speed probabilities. I volunteer my services to numerous Disaster Services Organizations. In June 2013 I returned from Hurricane Sandy deployment as a computer operations service associate with the Disaster Services Technology Group assisting as The American Red Cross migrated from a Disaster Response Operation to Long Term Recovery Operations. Pioneering the production/editing and Internet distribution of HD video to sites like Youtube.com and Vimeo.com we are shining the light towards environmental and peace efforts of humans across the globe. Since 1992 I have held the vision of establishing Maui, Hawaii as the environmental sciences center of the world. After His Holiness the 14th Dalai Lama of Tibet came to Maui This vision has expanded to establishing Maui as the environmental & peace center of the world.

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