CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice, humans

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RT@sciencemagazine CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice, humans 

Abstract:

Immunosuppressive tumor microenvironments can restrain antitumor immunity, particularly in pancreatic ductal adenocarcinoma (PDA). Because CD40 activation can reverse immune suppression and drive antitumor T cell responses, we tested the combination of an agonist CD40 antibody with gemcitabine chemotherapy in a small cohort of patients with surgically incurable PDA and observed tumor regressions in some patients. We reproduced this treatment effect in a genetically engineered mouse model of PDA and found unexpectedly that tumor regression required macrophages but not T cells or gemcitabine. CD40-activated macrophages rapidly infiltrated tumors, became tumoricidal, and facilitated the depletion of tumor stroma. Thus, cancer immune surveillance does not necessarily depend on therapy-induced T cells; rather, our findings demonstrate a CD40-dependent mechanism for targeting tumor stroma in the treatment of cancer.

 

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In 1995 At Maui High Performance Computing Center The Maui Scientific Analysis & Visualization of the Environment Program was first incubated. I was the principal investigator of this independant research project which was a joint development between MHPCC, Silicon Graphics Computers (SGI) & NKO.ORG. Using SGI Cosmo Worlds software, we pioneered the development of Internet based 3D virtual reality GIS based interactive worlds. In 1996 with a network of seven high performance SGI workstations we pioneered development of live streaming MPEG-1, MPEG-2, MPEG-4, Real Video and QuickTime Streaming Server utilizing Kassenna MediaBase software. In Maui 2002 we pioneered and tested the first wireless live streaming video using laptop computers and Maui Sky Fiber's portable 3G wireless device. In Maui we pioneered live streaming video using usb modems from AT&T , Verizon as well as live streaming from iPhone 3 over 3G wireless networks. Today The Maui S.A.V.E. Program has diversified into storm tracking including visualization and analysis of large, memory-intensive gridded data sets such as the National Hurricane Center's wind speed probabilities. I volunteer my services to numerous Disaster Services Organizations. In June 2013 I returned from Hurricane Sandy deployment as a computer operations service associate with the Disaster Services Technology Group assisting as The American Red Cross migrated from a Disaster Response Operation to Long Term Recovery Operations. Pioneering the production/editing and Internet distribution of HD video to sites like Youtube.com and Vimeo.com we are shining the light towards environmental and peace efforts of humans across the globe. Since 1992 I have held the vision of establishing Maui, Hawaii as the environmental sciences center of the world. After His Holiness the 14th Dalai Lama of Tibet came to Maui This vision has expanded to establishing Maui as the environmental & peace center of the world.

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